Why the study?
Does acetazolamide reduce steady-state carbon dioxide excretion in isolated bloodless lung preparations?
Population
Isolated bloodless lung preparations perfused with bicarbonate solutions
Comparison
Addition of acetazolamide vs Control conditions (without acetazolamide)
Design
Preclinical
Authors
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Extends mechanistic insight into lung carbonic anhydrase catalysis; leaves open translation to intact physiology or clinical use.
Does acetazolamide reduce steady-state carbon dioxide excretion in isolated bloodless lung preparations?
The study demonstrates that lung carbonic anhydrase significantly catalyzes the CO2 hydration-dehydration reaction in plasma by a factor of five.
Robert A. Klocke (1978) studied this question.
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