Key result
The velocity constants for CO2 hydration inside red blood cells were 236 and 772 sec–1, which decreased to 28 and 65 sec–1 in the presence of 0.25 g/liter acetazolamide.
Population
Human red blood cell suspensions
Comparison
Sudden alteration of Pco2 around the cells and… vs Uncatalyzed rate and uninhibited rate
Design
Preclinical
Authors
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Acetazolamide inhibits erythrocyte CO2 hydration kinetics; leaves open translation to human physiology or therapy.
This basic science study demonstrates the kinetics of CO2 hydration in human red blood cells and its inhibition by acetazolamide.
Constantine et al. (1965) studied this question. Acetazolamide vs. Uninhibited red blood cell suspensions was evaluated on Velocity constants for the hydration of CO2 inside the cell. The velocity constants for CO2 hydration inside red blood cells were 236 and 772 sec–1, which decreased to 28 and 65 sec–1 in the presence of 0.25 g/liter acetazolamide.
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