Key result
CO2 addition alters dog blood pH with a ~7 second half-time matching uncatalyzed hydration kinetics.
Population
Dog blood (in vitro) and dogs (in vivo)
Design
Preclinical
Authors
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Supports uncatalyzed CO2 hydration model in canine blood; leaves open translation to human acid-base kinetics.
The measured half-time of pH changes in dog blood in vitro and in vivo aligns with mathematical predictions based on uncatalyzed CO2 hydration kinetics.
Hill et al. (1977) studied this question. Addition of CO2 was evaluated on Apparent half time of pH change. The apparent half time of pH change in dog blood after CO2 addition was 6.0 +/- 0.5 s in vitro and 7.3 +/- 0.6 s in vivo, matching predictions based on uncatalyzed CO2 hydration kinetics.
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