Population
Isolated perfused canine hindlimb
Comparison
Varying arterial blood pH between 6.9 and 7.6 at… vs Different pH levels (within-subject comparison)
Design
Preclinical
Follow-up
10-min intervals
Authors
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Does not support clinical acid-base changes; leaves open pH dependence of skeletal muscle VO2 in intact humans.
Oxygen consumption of skeletal muscle appears critically dependent on extracellular fluid pH, with a 0.1 pH change altering VO2 by approximately 10%.
Alden H. Harken (1976) studied this question.
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