March 1, 1998The Journal of PhysiologyOpen Access

Functional and molecular expression of volume‐regulated chloride channels in canine vascular smooth muscle cells

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Population

Canine vascular smooth muscle cells from pulmonary and renal arteries

Design

Preclinical

Authors

JYJun YamazakiTokyo Medical University DDDayue Darrel DuanNanjing University of Chinese Medicine RJRobert JaniakUniversity of Nevada, Reno

Discussion

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Implication

Hypothesis-generating for ClC-3 in vascular volume regulation; leaves open contribution to myogenic tone in vivo.

Structured PICO

Population

Canine vascular smooth muscle cells from pulmonary and renal arteries

Intervention

Decreasing external osmolarity and application of channel blockers (DIDS, extracellular ATP, tamoxifen)

Outcome

Functional expression (Cl- currents via patch-clamp) and molecular expression (ClC-3 mRNA via RT-PCR) of volume-regulated chloride channelssurrogate

Volume-regulated chloride channels (ClC-3) are expressed in canine vascular smooth muscle cells and may contribute to the regulation of cell volume and myogenic tone.

Cite This Study

Yamazaki et al. (1998) studied this question.

synapsesocial.com/papers/6a81e2efcb8186709ca1fc45 https://doi.org/10.1111/j.1469-7793.1998.729bs.x

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Functional and molecular expression of volume‐regulated chloride channels in canine vascular smooth muscle cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Functional and molecular expression of volume‐regulated chloride channels in canine vascular smooth muscle cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider