Why the study?
Does the combined use of aspirin and clopidogrel before CABG increase the risk of excessive blood product transfusion in patients undergoing first CABG?
Population
659 individuals who underwent a first CABG, without concomitant valvular or aortic surgery, at a single…
Comparison
Aspirin, clopidogrel, or the combination of both… vs Neither aspirin nor clopidogrel prescribed…
Design
Cohort
Follow-up
up to the second post-operative day
Authors
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May warrant caution with dual antiplatelet therapy before CABG; leaves open whether to alter practice pending randomized confirmation.
Does the combined use of aspirin and clopidogrel before CABG increase the risk of excessive blood product transfusion in patients undergoing first CABG?
Combined use of aspirin and clopidogrel within 7 days prior to CABG is associated with a significantly increased risk of excessive perioperative blood product transfusion compared to no antiplatelet therapy.
Ray et al. (2003) studied this question.
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