March 1, 1990AJP Cell Physiology

Dissociation between myosin phosphorylation and shortening velocity in canine trachea

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Population

Canine trachealis (tracheal strips)

Design

Preclinical

Follow-up

60 minutes

Authors

LMLinda MerkelUniversity of Arizona WGWilliam T. GerthofferUniversity of Nevada, Reno TTT J TorphyNew Frontier

Discussion

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Implication

Challenges myosin-centric models of airway smooth muscle; hypothesis-generating for additional velocity regulators in preclinical research.

Structured PICO

Population

Canine trachealis (tracheal strips)

Intervention

Methacholine or K+ at various concentrations

Outcome

Relationship between glycogen phosphorylase activity, myosin light-chain phosphorylation, isotonic shortening velocity, and isometric tensionsurrogate

This preclinical study demonstrates that myosin phosphorylation is not the sole determinant of shortening velocity in canine tracheal smooth muscle.

Cite This Study

Merkel et al. (1990) studied this question.

synapsesocial.com/papers/6a81e6ce2ac899ae0206e552 https://doi.org/10.1152/ajpcell.1990.258.3.c524

View Full Paper

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Bookmark

Implication

Challenges myosin-centric models of airway smooth muscle; hypothesis-generating for additional velocity regulators in preclinical research.

Dissociation between myosin phosphorylation and shortening velocity in canine trachea

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Dissociation between myosin phosphorylation and shortening velocity in canine trachea

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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