Why the study?
Does omapatrilat reduce ambulatory blood pressure more than amlodipine in adults with mild-to-moderate hypertension?
Population
430 subjects age ≥18 years with mild-to-moderate hypertension.
Comparison
Omapatrilat once-daily for 10 weeks. vs Amlodipine once-daily for 10 weeks.
Design
RCT, Randomized into 2 parallel groups, Double-blind
Follow-up
10 weeks
Authors
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Supports omapatrilat preference over amlodipine for ambulatory BP control; extends RCT evidence in mild-to-moderate hypertension.
Does omapatrilat reduce ambulatory blood pressure more than amlodipine in adults with mild-to-moderate hypertension?
Omapatrilat 80 mg provides superior blood pressure lowering compared to amlodipine 10 mg in patients with mild-to-moderate hypertension.
Luís M. Ruilope (2000) studied this question.
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