Omapatrilat compared with lisinopril in treatment of hypertension as assessed by ambulatory blood pressure monitoring

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Why the study?

Does omapatrilat reduce ambulatory blood pressure compared to lisinopril in adults with hypertension?

Structured PICO

Does omapatrilat reduce ambulatory blood pressure compared to lisinopril in adults with hypertension?

Population

347 adults (age ≥18 years) with hypertension (systolic blood pressure 150–180 mm Hg) after a 4-week washout of prior antihypertensive medications.

Intervention

Omapatrilat once-daily (20 mg force-titrated to 40 mg at week 2 and to 80 mg at week 8) for 10 weeks.

Comparator

Lisinopril once-daily (10 mg force-titrated to 20 mg at week 2 and to 40 mg at week 4) for 10 weeks.

Outcome

Change from baseline in 24-hour mean ambulatory systolic blood pressure (ASBP), diastolic BP (ADBP), and mean BP (AMBP) after 10 weeks.surrogate

Omapatrilat 80 mg was superior to lisinopril 40 mg in reducing 24-hour ambulatory systolic and diastolic blood pressure over 10 weeks.

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Omapatrilat may be preferred over lisinopril for ambulatory BP control; confirms dual vasopeptidase inhibition superiority in hypertension RCT.

Roland Asmar (2000) studied this question.

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Omapatrilat may be preferred over lisinopril for ambulatory BP control; confirms dual vasopeptidase inhibition superiority in hypertension RCT.