Why the study?
Does omapatrilat reduce blood pressure more than lisinopril in salt-sensitive hypertensives?
Population
57 salt-sensitive hypertensives (SSH) identified by the Grim-Weinberger Protocol
Comparison
Omapatrilat 40 mg for 3 weeks after a 1-week… vs Lisinopril 20 mg for 3 weeks after a 1-week…
Design
RCT, randomized
Follow-up
28 days
Authors
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Supports omapatrilat preference in salt-sensitive hypertension; confirms benefit of dual ACE-neprilysin inhibition over ACE inhibition alone.
Does omapatrilat reduce blood pressure more than lisinopril in salt-sensitive hypertensives?
Omapatrilat is more effective than lisinopril at lowering blood pressure in salt-sensitive hypertensives, likely due to a non-ACE inhibitory mechanism involving ANP.
V. M. Campese (2000) studied this question.
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