September 1, 1992BloodOpen Access

Human neutrophils synthesize thrombomodulin that does not promote thrombin-dependent protein C activation

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Population

Human neutrophils (PMN) isolated from human leukocytes

Comparison

Evaluation of thrombomodulin expression… vs Human umbilical vein endothelial cells and human…

Design

Preclinical

Authors

ECEdward M. ConwayUniversity of British Columbia BNB NowakowskiUniversity of Iowa MSMarta Steiner‐MosonyiUniversity of Guelph

Discussion

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Implication

May link neutrophil inflammation to thrombosis; leaves open stimulation-dependent protein C activation.

Structured PICO

Population

Human neutrophils (PMN) isolated from human leukocytes

Intervention

Evaluation of thrombomodulin (TM) expression, localization, and biologic function

Comparator

Human umbilical vein endothelial cells (HUVEC) and human placenta

Outcome

Presence, localization, and biologic function of thrombomodulin in neutrophilssurrogate

Human neutrophils synthesize thrombomodulin, but it does not promote thrombin-dependent protein C activation under nonstimulated conditions, suggesting a potential link between inflammation and thrombosis.

Cite This Study

Conway et al. (1992) studied this question.

synapsesocial.com/papers/6a81f294e02763da79e044ce https://doi.org/10.1182/blood.v80.5.1254.1254

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Human neutrophils synthesize thrombomodulin that does not promote thrombin-dependent protein C activation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Human neutrophils synthesize thrombomodulin that does not promote thrombin-dependent protein C activation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider