Why the study?
Does Sca-1 overexpression or deficiency alter cardiac hypertrophy and fibrosis following pressure overload in mice?
Population
Sca-1 cardiac-specific transgenic mice, Sca-1 knockout mice, and their wild-type littermates subjected to…
Comparison
Sca-1 overexpression or Sca-1 deficiency vs Wild-type littermates
Design
Preclinical
Follow-up
4 weeks
Authors
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Sca-1 modulation attenuates murine pressure-overload remodeling; hypothesis-generating for therapeutic targeting in human HF.
Does Sca-1 overexpression or deficiency alter cardiac hypertrophy and fibrosis following pressure overload in mice?
Sca-1 protects against pressure overload-induced cardiac hypertrophy and fibrosis by regulating multiple signaling pathways in cardiomyocytes.
Zhou et al. (2012) studied this question.
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