June 1, 1995Journal of VirologyOpen Access

Foot-and-mouth disease virus Lb proteinase can stimulate rhinovirus and enterovirus IRES-driven translation and cleave several proteins of cellular and viral origin

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Structured PICO

Population

In vitro translation systems (rhinovirus, enterovirus, cardiovirus, FMDV IRES) and various target proteins (Xenopus laevis cyclin B2, influenza virus NS, mengovirus polypeptide, human cyclin A, poliovirus replicase-related polypeptides)

Intervention

Purified recombinant FMDV Lb proteinase

Comparator

Inhibitor or mutant Lb proteinase

Outcome

Stimulation of IRES-driven translation initiation and specific cleavage of target proteinssurrogate

FMDV Lb proteinase can stimulate rhinovirus and enterovirus IRES-driven translation and cleave various cellular and viral proteins, highlighting its functional versatility.

Discussion

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Implication

Does not support antiviral strategy changes; leaves open whether FMDV Lb effects extend to in vivo picornavirus models.

Cite This Study

Ziegler et al. (1995) studied this question.

synapsesocial.com/papers/6a8212646cfba4e31a9fd864 https://doi.org/10.1128/jvi.69.6.3465-3474.1995

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Ask AI

Bookmark

Foot-and-mouth disease virus Lb proteinase can stimulate rhinovirus and enterovirus IRES-driven translation and cleave several proteins of cellular and viral origin

Structured PICO

Discussion

Implication

Cite This Study

Foot-and-mouth disease virus Lb proteinase can stimulate rhinovirus and enterovirus IRES-driven translation and cleave several proteins of cellular and viral origin

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider