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September 1, 1994Journal of VirologyOpen Access

Foot-and-mouth disease virus leader proteinase: purification of the Lb form and determination of its cleavage site on eIF-4 gamma

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Population

In vitro models including Escherichia coli expressing the Lb form of the leader proteinase and eIF-4 gamma…

Comparison

Purification of the Lb form of the leader… vs Human rhinovirus type 2 2A proteinase and in…

Design

Preclinical

Authors

RKR KirchwegerCentre National de la Recherche ScientifiqueEZErika ZieglerSaarland UniversityBLBarry J. LamphearLouisiana State University

Discussion

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Implication

May enable selective FMDV inhibitors; extends picornavirus protease maps but leaves open therapeutic translation.

Structured PICO

P
Population
In vitro models including Escherichia coli expressing the Lb form of the leader proteinase and eIF-4 gamma from rabbit reticulocyte
I
Intervention
Purification of the Lb form of the leader proteinase and determination of its cleavage site on eIF-4 gamma
C
Comparator
Human rhinovirus type 2 2A proteinase and in vivo infection products
O
Outcome
Cleavage site of the leader proteinase in eIF-4 gamma

The study identifies the specific cleavage site of the foot-and-mouth disease virus leader proteinase on eIF-4 gamma, highlighting a distinct mechanism from other picornaviruses.

Cite This Study

Kirchweger et al. (1994) studied this question.

synapsesocial.com/papers/6a6f56d731a3df824327bb5dhttps://doi.org/10.1128/jvi.68.9.5677-5684.1994
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cleavage specificity on synthetic peptide substrates of human rhinovirus 2 proteinase 2A.1992 · 74 citations
  2. 2A second protease of foot-and-mouth disease virus1986 · 183 citations
  3. 3Eukaryotic initiation factor 3 is required for poliovirus 2A protease-induced cleavage of the p220 component of eukaryotic initiation factor 4F.1990 · 63 citations
  4. 4Putative papain‐related thiol proteases of positive‐strand RNA viruses Identification of rubi‐ and aphthovirus proteases and delineation of a novel conserved domain associated with proteases of rubi‐, α‐ and coronaviruses1991 · 340 citations
  5. 5Restriction of translation of capped mRNA in vitro as a model for poliovirus-induced inhibition of host cell protein synthesis: relationship to p220 cleavage1987 · 58 citations