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January 17, 2021Journal of the American Heart AssociationOpen Access

Habitation Altitude and Left Ventricular Diastolic Function: A Population‐Based Study

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Why the study?

Although numerous studies have evaluated the positive or negative effects of altitude on cardiovascular disease, results remain conflicting.

Does habitation at higher altitude increase the risk of left ventricular diastolic dysfunction in adults?

Population

34 215 residents aged >=35 years in China

Comparison

Middle (1500-3500 m) and high (>=3500 m) vs low (<1500 m) habitation altitude

Design

Cross-sectional survey study

Authors

CZCongyi ZhengAcademy of Medical SciencesXWXin WangElectrophysiologyHTHaosu TangUniversity of Sheffield

Discussion

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Implication

Higher altitude was associated with LVDD odds; leaves open causal inference and need for longitudinal studies before clinical consideration.

Structured PICO

Does habitation at higher altitude increase the risk of left ventricular diastolic dysfunction in adults?

P
Population
34,215 residents in China, aged ≥35 years (mean age 55.87 years, 45.92% men), living at altitudes ranging from 3.1 to 4507 m.
I
Intervention
Habitation at middle (1500–3500 m) or high (≥3500 m) altitude
C
Comparator
Habitation at low altitude (<1500 m)
O
Outcome
Left ventricular diastolic dysfunction (LVDD) defined by 2009 American Society of Echocardiography guidelinessurrogate

Living at altitudes above 1500 m is associated with a significantly increased risk of left ventricular diastolic dysfunction, particularly in men.

Cite This Study

Zheng et al. (2021) studied this question.

synapsesocial.com/papers/6a8216a0d96cdbb40a9cd1d0https://doi.org/10.1161/jaha.120.018079

Topics

Echocardiography
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