Why the study?
Does a low dose combination of ramipril and felodipine ER reduce blood pressure in patients with mild to moderate essential hypertension?
Population
20 patients with uncomplicated mild to moderate hypertension.
Comparison
Combination of ramipril 2.5 mg and felodipine ER… vs Placebo, monotherapy with ramipril 2.5 mg, and…
Design
RCT, randomised, double-blind, double dummy placebo controlled
Follow-up
4 weeks per phase
Authors
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Supports low-dose ramipril-felodipine for additive ambulatory BP control in mild hypertension; confirms additive ACEI-CCB efficacy in essential hypertension.
Does a low dose combination of ramipril and felodipine ER reduce blood pressure in patients with mild to moderate essential hypertension?
A low-dose combination of ramipril and felodipine ER provides additive blood pressure reduction in mild to moderate hypertension without attenuating felodipine-induced headaches.
BAINBRIDGE et al. (1993) studied this question.
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