Why the study?
Does felodipine, enalapril, or their combination reduce blood pressure compared to placebo in elderly patients with systolic hypertension?
Population
20 elderly subjects (7 male, 13 female, ages 61-87 years) with systolic hypertension.
Comparison
Felodipine 5-20 mg once daily, enalapril 5-20 mg… vs Placebo for 6 weeks.
Design
RCT, Randomised crossover design with Latin square allocation of treatments…
Follow-up
6 weeks per treatment phase
Authors
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Favors felodipine-based regimens over enalapril monotherapy for BP lowering in elderly systolic hypertension; extends comparative RCT evidence on CCBs versus ACEIs.
Does felodipine, enalapril, or their combination reduce blood pressure compared to placebo in elderly patients with systolic hypertension?
In elderly patients with systolic hypertension, felodipine effectively lowers blood pressure but causes more vasodilator adverse effects, whereas enalapril is better tolerated but less effective as monotherapy.
Wing et al. (1994) studied this question.
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