Why the study?
Does felodipine compared to enalapril improve blood pressure in patients with essential hypertension?
Population
35 subjects with essential hypertension (22 male, 13 female, median age 48 years, range 31-69 years)
Comparison
Felodipine 5-20 mg orally once daily for 8 weeks vs Enalapril 5-20 mg orally once daily for 8 weeks
Design
RCT, randomised crossover design, double-blind
Follow-up
8 weeks per treatment phase
Authors
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Either agent may be selected based on tolerability; confirms equivalent BP-lowering efficacy in essential hypertension.
Does felodipine compared to enalapril improve blood pressure in patients with essential hypertension?
Felodipine and enalapril monotherapy provide similar antihypertensive efficacy but have distinct adverse effect profiles in patients with essential hypertension.
Watts et al. (1993) studied this question.
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