Why the study?
Does low-dose combination therapy (enalapril + felodipine ER) improve blood pressure reduction compared to an increased dose of monotherapy (enalapril) in patients with hypertension?
Population
217 patients with hypertension who completed a 2-week placebo run-in and 3 weeks of 5 mg enalapril once daily
Comparison
Low-dose combination therapy for 6 weeks vs Higher dose of monotherapy for 6 weeks
Design
RCT, randomized, double-blind
Follow-up
6 weeks (initial parallel phase), up to 12 weeks total
Authors
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Supports low-dose combination over monotherapy uptitration for BP control; extends RCT evidence for complementary dual therapy in hypertension.
Does low-dose combination therapy (enalapril + felodipine ER) improve blood pressure reduction compared to an increased dose of monotherapy (enalapril) in patients with hypertension?
In hypertensive patients not achieving goal blood pressure on low-dose monotherapy, adding a second agent with a complementary mechanism is more effective than doubling the dose of the initial agent.
W.J. Elliott (1999) studied this question.
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