Why the study?
Does a low-dose combination of felodipine and enalapril improve blood pressure reduction compared to higher-dose monotherapy in elderly subjects with essential hypertension?
Population
36 elderly subjects with essential hypertension, mean age 67 ± 6 years.
Comparison
Combination of felodipine 5 mg and enalapril 5… vs Felodipine 10 mg once daily OR enalapril 10 mg…
Design
RCT, balanced Latin square design, double-blind
Follow-up
6 weeks per treatment period
Authors
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Supports low-dose felodipine-enalapril over higher-dose monotherapy for BP control in elderly hypertensives; extends evidence favoring initial combinations.
Does a low-dose combination of felodipine and enalapril improve blood pressure reduction compared to higher-dose monotherapy in elderly subjects with essential hypertension?
A low-dose combination of felodipine and enalapril provides superior blood pressure reduction and better tolerability compared to higher-dose monotherapy with either drug in elderly hypertensive patients.
Morgan et al. (1992) studied this question.
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