April 29, 2005Arteriosclerosis Thrombosis and Vascular Biology

Binding and Internalization of C-Reactive Protein by Fcgamma Receptors on Human Aortic Endothelial Cells Mediates Biological Effects

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Population

Human aortic endothelial cells (HAECs)

Comparison

Incubation with biotinylated C-reactive protein… vs Control conditions

Design

Preclinical

Authors

SDSridevi DevarajBaylor College of Medicine TCTerry W. Du ClosRush University Medical Center IJIshwarlal JialalGeneral / Preventive / Lipids

Discussion

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Implication

No immediate clinical implications; hypothesis-generating for CRP's endothelial effects via CD32/CD64, requiring in vivo confirmation.

Structured PICO

Population

Human aortic endothelial cells (HAECs)

Intervention

Incubation with biotinylated C-reactive protein (CRP, 25 to 200 microg/mL) and antibodies to CD32 and CD64

Comparator

Control conditions (e.g., no CRP, or CRP without blocking antibodies)

Outcome

Binding and internalization of CRP by HAECssurrogate

CRP mediates its pro-atherothrombotic biological effects on human aortic endothelial cells via binding and internalization through Fcgamma receptors CD32 and CD64.

Cite This Study

Devaraj et al. (2005) studied this question.

synapsesocial.com/papers/6a8219d794037d46bac69f00 https://doi.org/10.1161/01.atv.0000168573.10844.ae

View Full Paper

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Binding and Internalization of C-Reactive Protein by Fcgamma Receptors on Human Aortic Endothelial Cells Mediates Biological Effects

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Binding and Internalization of C-Reactive Protein by Fcgamma Receptors on Human Aortic Endothelial Cells Mediates Biological Effects

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider