What question did this study set out to answer?

To examine the aetiology and identify preventable risk factors for adenocarcinoma of the oesophagus in women.

July 1, 2000British Journal of CancerOpen Access

A case-control study of oesophageal adenocarcinoma in women: a preventable disease

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Authors

KCKar Keung ChengUniversity of Birmingham LSLinda SharpNewcastle University PMP A McKinneyUniversity of Leeds

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Implication

Case-control study reveals that high early-adulthood BMI and low fruit intake increase oesophageal adenocarcinoma risk in women, highlighting substantial opportunities for prevention.

Key Points

To examine the aetiology and identify preventable risk factors for adenocarcinoma of the oesophagus in women.
Conducted a multicentre, population-based case-control study across four regions in England and Scotland.
Recruited 74 female incident cases with histologically confirmed oesophageal adenocarcinoma and 74 female controls matched by age and general practice.
High body mass index at age 20 years markedly elevated cancer risk (highest vs lowest quartile, adjusted OR = 6.04, 95% CI 1.28–28.52), whereas high fruit consumption was protective (highest vs lowest quartile, adjusted OR = 0.08, 95% CI 0.01–0.49).
Breastfeeding significantly reduced risk (ever vs never, adjusted OR = 0.41, 95% CI 0.20–0.82) with a dose-response effect by duration, yielding an overall population attributable risk of 96% for all three factors.

Cite This Study

Cheng et al. (2000) studied this question.

synapsesocial.com/papers/6a8219f509aaa8d1a6f25216 https://doi.org/10.1054/bjoc.2000.1121

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Implication

Case-control study reveals that high early-adulthood BMI and low fruit intake increase oesophageal adenocarcinoma risk in women, highlighting substantial opportunities for prevention.

A case-control study of oesophageal adenocarcinoma in women: a preventable disease

Discussion

Member takes

Implication

Key Points

Cite This Study

A case-control study of oesophageal adenocarcinoma in women: a preventable disease

Discussion

Member takes

Implication

Key Points

Cite This Study

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