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Design
Review
This review summarizes the role of biochemical markers, particularly high-sensitivity cardiac troponins, in the early diagnosis and risk stratification of acute myocardial infarction.
ZĂĄkladem diagnostiky myokardiĂĄlnĂ nekrĂłzy pĹi akutnĂm infarktu myokardu (AIM) i z jinĂ˝ch pĹĂÄin je jiĹž Ĺadu let vyĹĄetĹenĂ plazmatickĂ˝ch koncentracĂ srdeÄnĂch troponinĹŻ. DalĹĄĂ markery myokardiĂĄlnĂho poĹĄkozenĂ, jako jsou myoglobin, vazebnĂ˝ protein pro mastnĂŠ kyseliny, isoenzym BB glykogen fosforylĂĄzy nebo ÄasnĂ˝ a citlivĂ˝ marker celkovĂŠho stresu kopeptin, zĹŻstĂĄvajĂ zatĂm stĂĄle jen zajĂmavou moĹžnostĂ pĹedevĹĄĂm pĹi ÄasnĂŠm vyluÄovĂĄnĂ AIM a v rizikovĂŠ stratifikaci. V poslednĂch letech byly do rutinnĂ praxe zavedeny vysoce senzitivnĂ metody vyĹĄetĹenĂ srdeÄnĂch troponinĹŻ umoĹžĹujĂcĂ zĂĄchyt diagnostickĂ˝ch vzestupĹŻ plazmatickĂ˝ch koncentracĂ jiĹž v prvnĂch hodinĂĄch postiĹženĂ srdeÄnĂho svalu. PomocĂ tÄchto metod jsou vĹĄak nachĂĄzeny nĂzkĂŠ plazmatickĂŠ koncentrace velmi Äasto u primĂĄrnÄ nekardiĂĄlnĂch onemocnÄnĂ i u zdravĂ˝ch nebo zdĂĄnlivÄ zdravĂ˝ch osob. Problematika proto stĂĄle zasluhuje pozornost.
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Tomáš Janota (2014) studied this question.
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