Key result
Elevated neutrophil-lymphocyte ratio is linked to severe degenerative aortic stenosis and correlates with peak gradient.
Why the study?
Degenerative aortic stenosis and atherosclerosis share a common pathogenic mechanism, motivating an evaluation of the association between the neutrophil-lymphocyte ratio (NLR) and the presence and severity of degenerative aortic valve stenosis.
Is the Neutrophil-Lymphocyte Ratio (NLR) associated with the presence and severity of degenerative aortic valve stenosis?
Case-Control (n=138)
No
Is the Neutrophil-Lymphocyte Ratio (NLR) associated with the presence and severity of degenerative aortic valve stenosis?
This study aims to evaluate whether the neutrophil-lymphocyte ratio can serve as a marker for the presence and severity of degenerative aortic valve stenosis.
NLR elevation may mark severe aortic stenosis severity; leaves open its role as a noninvasive biomarker pending prospective validation.
Objective: In different studies, it has been shown that degenerative aortic stenosis and atherosclerosis had a common pathogenic mechanism. The goal of this study was to examine the association between NLR and the presence and severity of degenerative aortic valve stenosis. Methods : Echocardiographic data (from May 2011 to September 2013) of our cardiology department was reviewed retrospectively. After evaluation according to exclusion criteria’s, a total of 103 patients with degenerative AS and a control group of 35 age- and gender- matched patients who had normal echocardiographic findings were included in the study. Results: The level of NLR was highest in severe AS. The neutrophil-lymphocyte ratio was significantly higher in severe AS group than for the mild and moderate AS group (1.95±0.42, 2.31±0.69, 2.67±0.73; p<0.001 respectively). In comparison of the degenerative aortic stenosis groups with the control group, NLR in all aortic stenosis groups was found to be significantly higher than the control group (p<0.001). In addition, there was a statistically significant correlation between NLR and transaortic peak pressure gradient in patients with degenerative aortic stenosis (r: 0.626, p<0.001). Conclusion: The NLR, which is an inexpensive and readily available marker of chronic inflammation, may be useful in predicting the presence and severity of degenerative aortic stenosis.
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A 2016 study conducted a case-control in Degenerative aortic valve stenosis (n=138). Neutrophil-lymphocyte ratio (NLR) vs. Normal echocardiographic control group and milder aortic stenosis severity groups was evaluated on Mean neutrophil-lymphocyte ratio (NLR) in severe degenerative aortic stenosis vs control group (r 0.626 for correlation with transaortic peak pressure gradient, p=<0.001). Neutrophil-lymphocyte ratio was significantly higher in severe degenerative aortic stenosis than in controls (2.67 vs 1.5, p<0.001) and correlated with peak gradient (r=0.626, p<0.001).
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