Population
556 normotensive or never-treated hypertensive patients without kidney disease, mean age 46 years.
Design
Cross-sectional
Authors
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Hypothesis-generating for early kidney impairment in hypertension pathogenesis; prospective studies needed before any clinical implications.
Even in the absence of clinical kidney disease, lower eGFR is associated with higher blood pressure and systemic vascular resistance, suggesting early kidney impairment may contribute to essential hypertension pathogenesis.
Vääräniemi et al. (2014) studied this question.
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