May 30, 2014Clinical Journal of the American Society of NephrologyOpen Access

A Randomized, Open-Label, Dose-Response Study of Losartan in Hypertensive Children

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Why the study?

Does a higher dose of losartan improve blood pressure reduction compared to a lower dose in hypertensive children aged 6 months to 6 years?

Population

101 hypertensive children aged 6 months to 6 years

Comparison

Losartan at dosages of 0.3 mg/kg per day or 0.7… vs Losartan at 0.1 mg/kg per day (low dose)

Design

RCT, Randomized, Open-label

Follow-up

12 weeks, with a 2-year extension

Authors

NWNicholas J.A. WebbNovartis (Switzerland)TWThomas G. WellsLeiden University SSShahnaz ShahinfarChildren's Hospital of Philadelphia

Discussion

Member takes

Implication

Lower losartan doses may suffice for BP control in hypertensive children under 6 years; challenges assumptions of dose-dependent efficacy.

Structured PICO

Does a higher dose of losartan improve blood pressure reduction compared to a lower dose in hypertensive children aged 6 months to 6 years?

Population

101 hypertensive children aged 6 months to 6 years

Intervention

Losartan at dosages of 0.3 mg/kg per day (medium) or 0.7 mg/kg per day (high), titrated up to a maximum of 1.4 mg/kg per day

Comparator

Losartan at 0.1 mg/kg per day (low dose)

Outcome

Slope of change in sitting systolic BP (SBP) after 3 weeks compared with baselinesurrogate

Losartan effectively lowers blood pressure in hypertensive children aged 6 months to 6 years, but there is no evident dose-response relationship between 0.1 and 0.7 mg/kg per day.

Cite This Study

Webb et al. (2014) studied this question.

synapsesocial.com/papers/6a8239d4f337522b6774ae1f https://doi.org/10.2215/cjn.11111113

Topics

Hypertension management

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May 30, 2014Clinical Journal of the American Society of NephrologyOpen Access

A Randomized, Open-Label, Dose-Response Study of Losartan in Hypertensive Children

View Full Paper

Ask AI

Bookmark

Why the study?

Does a higher dose of losartan improve blood pressure reduction compared to a lower dose in hypertensive children aged 6 months to 6 years?

Population

101 hypertensive children aged 6 months to 6 years

Comparison

Losartan at dosages of 0.3 mg/kg per day or 0.7… vs Losartan at 0.1 mg/kg per day (low dose)

Design

RCT, Randomized, Open-label

Follow-up

12 weeks, with a 2-year extension

Authors

NWNicholas J.A. WebbNovartis (Switzerland)TWThomas G. WellsLeiden University SSShahnaz ShahinfarChildren's Hospital of Philadelphia

Discussion

Member takes

Implication

Lower losartan doses may suffice for BP control in hypertensive children under 6 years; challenges assumptions of dose-dependent efficacy.

Structured PICO

Does a higher dose of losartan improve blood pressure reduction compared to a lower dose in hypertensive children aged 6 months to 6 years?

Population

101 hypertensive children aged 6 months to 6 years

Intervention

Losartan at dosages of 0.3 mg/kg per day (medium) or 0.7 mg/kg per day (high), titrated up to a maximum of 1.4 mg/kg per day

Comparator

Losartan at 0.1 mg/kg per day (low dose)

Outcome

Slope of change in sitting systolic BP (SBP) after 3 weeks compared with baselinesurrogate

Losartan effectively lowers blood pressure in hypertensive children aged 6 months to 6 years, but there is no evident dose-response relationship between 0.1 and 0.7 mg/kg per day.

Cite This Study

Webb et al. (2014) studied this question.

synapsesocial.com/papers/6a8239d4f337522b6774ae1f https://doi.org/10.2215/cjn.11111113

Also Consider

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Topics

Hypertension management

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