Randomized, Double-Blind, Controlled Study of Losartan in Children with Proteinuria

306 children aged 1 to 17 years with proteinuria (morning-void urinary protein-creatinine ratio baseline >= 0.3 g/g), with or without hypertension, in a multinational setting.

Losartan 0.7 to 1.4 mg/kg per day for 12 weeks.

Placebo (for normotensive stratum) or amlodipine 0.1 to 0.2 mg/kg per day up to 5 mg/d (for hypertensive stratum).

Change in proteinuria (morning-void urinary protein-creatinine ratio) at 12 weeks.surrogate