Why the study?
While NSTEMI processes of care vary by sex, little is known regarding practice variation between geographical areas and centres.
Does female sex and regional variation in quality of care affect in-hospital mortality and MACE in patients admitted with NSTEMI?
Does female sex and regional variation in quality of care affect in-hospital mortality and MACE in patients admitted with NSTEMI?
In this nationwide UK cohort of 305,014 NSTEMI admissions, women consistently received lower quality care and fewer invasive procedures across all regions compared to men, and hospital-level adherence to quality indicators was more strongly associated with reduced mortality in women than in men.
Answers are grounded in this paper and cite their sources.
Sex and geographic disparities in NSTEMI care persist; leaves open whether targeted interventions improve equity and outcomes.
BACKGROUND: Contemporary studies demonstrate that non-ST-segment elevation myocardial infarction (NSTEMI) processes of care vary according to sex. Little is known regarding variation in practice between geographical areas and centres. METHODS: We identified 305 014 NSTEMI admissions in the United Kingdom (UK) Myocardial Ischaemia National Audit Project (MINAP), 2010-17, including female sex (110 209). Hierarchical, multivariate logistic regression models were fitted, assessing for differences in primary outcomes according to sex. Risk-standardized mortality rates (RSMR) were calculated for individual hospitals to illustrate the correlation with variables of interest. 'Heat maps' were plotted to show regional and sex-based variation in the opportunity-based quality indicator score (surrogate for optimal processes of care). RESULTS: Women presented older (77 years vs. 69 years, P < 0.001) and were more often Caucasian (93% vs. 91%, P < 0.001). Women were less frequently managed with an invasive coronary angiogram (58% vs. 75%, P < 0.001) or percutaneous coronary intervention (35% vs. 49%, P < 0.001). In our hospital-clustered analysis, we show a positive correlation between the RSMR and the increasing proportion of women treated for NSTEMI (R2 = 0.17, P < 0.001). There was a clear negative correlation between the proportion of women who had an optimum OBQI score during their admission and RSMR (R2 = 0.22, P < 0.001), with a weaker correlation in men (R2 = 0.08, P < 0.001). Heat maps according to the Clinical Commissioning Group (CCG) demonstrate significant regional variation in the OBQI score, with women receiving poorer quality care throughout the UK. CONCLUSION: There was a significant variation in the management of patients with NSTEMI according to sex, with widespread geographical variation. Structural changes are required to enable improved care for women.
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Weight et al. (2024) studied this question.
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