What question did this study set out to answer?

To evaluate the relationship between elevated fasting blood glucose levels and short-term as well as 6-month mortality across the entire spectrum of acute coronary syndromes.

February 23, 2009Archives of Internal MedicineOpen Access

Association of Elevated Fasting Glucose With Increased Short-term and 6-Month Mortality in ST-Segment Elevation and Non–ST-Segment Elevation Acute Coronary Syndromes

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To evaluate the relationship between elevated fasting blood glucose levels and short-term as well as 6-month mortality across the entire spectrum of acute coronary syndromes.
Analyzed 13,526 patients with acute coronary syndromes from the multicenter Global Registry of Acute Coronary Events.
Used multivariate logistic regression adjusted for established registry risk score covariates to evaluate in-hospital and 6-month postdischarge outcomes.
Higher fasting glucose demonstrated a graded increase in in-hospital mortality compared with <100 mg/dL: OR 1.51 (95% CI, 1.12–2.04) for 100–125 mg/dL, OR 2.20 (95% CI, 1.64–2.60) for 126–199 mg/dL, OR 5.11 (95% CI, 3.52–7.43) for 200–299 mg/dL, and OR 8.00 (95% CI, 4.76–13.5) for ≥300 mg/dL.
Postdischarge mortality at 6 months was significantly higher for fasting glucose levels of 126–199 mg/dL (OR 1.71; 95% CI, 1.25–2.34) and ≥300 mg/dL (OR 2.93; 95% CI, 1.33–6.43).
Continuous fasting glucose predicted in-hospital death without a clear threshold, maintaining a consistent association regardless of prior diabetes mellitus history.

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Implication

Multicenter registry study demonstrates elevated fasting glucose increases in-hospital and 6-month mortality in acute coronary syndrome, highlighting continuous risk across diabetic status.

Cite This Study

Peter Sinnaeve (2009) studied this question.

synapsesocial.com/papers/6a823b88546f28f1897956bb https://doi.org/10.1001/archinternmed.2008.572

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Implication

Multicenter registry study demonstrates elevated fasting glucose increases in-hospital and 6-month mortality in acute coronary syndrome, highlighting continuous risk across diabetic status.

Association of Elevated Fasting Glucose With Increased Short-term and 6-Month Mortality in ST-Segment Elevation and Non–ST-Segment Elevation Acute Coronary Syndromes

Key Points

Discussion

Implication

Cite This Study

Association of Elevated Fasting Glucose With Increased Short-term and 6-Month Mortality in ST-Segment Elevation and Non–ST-Segment Elevation Acute Coronary Syndromes

Key Points

Discussion

Implication

Cite This Study