Why the study?
Does high-dose loperamide abuse cause ventricular arrhythmias, and can isoproterenol prevent them?
Does high-dose loperamide abuse cause ventricular arrhythmias, and can isoproterenol prevent them?
High-dose loperamide abuse can cause reversible ventricular arrhythmias, including torsades de pointes, which may be managed with isoproterenol.
High-dose loperamide abuse warrants consideration in unexplained ventricular arrhythmias; this case leaves open isoproterenol's preventive role.
Tabled 1KEY TEACHING POINTS•Loperamide, when taken chronically in large doses, can cause significant conduction abnormalities and ventricular arrhythmias that are reversible upon discontinuation of the drug.•Isoproterenol may serve as a useful adjunct for preventing loperamide-induced ventricular arrhythmias, particularly torsades de pointes.•Familiarity with and recognition of the dangers of loperamide abuse may preclude unnecessary diagnostics and invasive procedures. Open table in a new tab
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O'Connell et al. (2016) studied this question.
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