Insulin deficiency decreases mesangial cell contractility via increased PGE2 production and reduced intracellular calcium sensitivity, potentially contributing to diabetic hyperfiltration.
No takes yet. Share an insight, caveat, or question.
May impair mesangial contractility in insulin deficiency; leaves open contribution to diabetic hyperfiltration and need for human studies.
Dunlop et al. (1990) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: