October 1, 2003Journal of Applied Physiology

Effects of exercise training on acclimatization to hypoxia: systemic O2 transport during maximal exercise

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Population

26 rats divided into acclimatized trained, nonacclimatized trained, acclimatized sedentary, and…

Comparison

Exercise training for 3 weeks followed by living… vs Sedentary acclimatized and nonacclimatized rats.

Design

Preclinical

Follow-up

31 days (3 weeks + 10 days)

Authors

FFFabrice FavretUniversité de Strasbourg KHKyle K. HendersonMidwestern University JRJean‐Paul RichaletCross-Cutting Cardiology

Discussion

Member takes

Implication

Supports training to preserve VO2 max in hypoxic rats; leaves open translation to human acclimatization.

Structured PICO

Population

26 rats divided into acclimatized trained (n=6), nonacclimatized trained (n=6), acclimatized sedentary (n=6), and nonacclimatized sedentary (n=8) groups.

Intervention

Exercise training for 3 weeks followed by living at inspired Po2 of 70 Torr for 10 days while continuing to train in normoxia.

Comparator

Sedentary acclimatized and nonacclimatized rats.

Outcome

Maximal O2 uptake (Vo2 max), cardiac output (Q), maximal heart rate (HR-max), and myocardial beta-adrenoceptor density.surrogate

Exercise training preserves cardiac output and maximal oxygen uptake during acclimatization to hypoxia by attenuating myocardial beta-adrenoceptor downregulation.

Cite This Study

Favret et al. (2003) studied this question.

synapsesocial.com/papers/6a8250afa8461dff0846c95e https://doi.org/10.1152/japplphysiol.01220.2001

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Effects of exercise training on acclimatization to hypoxia: systemic O2 transport during maximal exercise

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of exercise training on acclimatization to hypoxia: systemic O2 transport during maximal exercise

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider