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November 16, 2016Annals of Surgery

Perioperative Pharmacological Thromboprophylaxis in Patients With Cancer

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Why the study?

Does perioperative pharmacological thromboprophylaxis reduce venous thromboembolism in cancer patients undergoing surgery?

Population

Cancer patients undergoing surgery (39 studies)

Comparison

Perioperative pharmacological thromboprophylaxis vs No pharmacological thromboprophylaxis

Design

Meta-analysis

Authors

QGQiang GuoShenzhen UniversityBHBin HuangUniversity of South AustraliaJZJichun ZhaoSouthwest University

Discussion

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Implication

Supports individualized perioperative thromboprophylaxis decisions in cancer surgery; confirms DVT benefit while underscoring bleeding trade-off in Level 1 evidence.

Structured PICO

Does perioperative pharmacological thromboprophylaxis reduce venous thromboembolism in cancer patients undergoing surgery?

P
Population
Cancer patients undergoing surgery (39 studies)
I
Intervention
Perioperative pharmacological thromboprophylaxis (including low-molecular-weight heparin [LMWH] and unfractionated heparin [UFH])
C
Comparator
No pharmacological thromboprophylaxis (also included comparisons of LMWH vs UFH, and extended vs conventional thromboprophylaxis)
O
Outcome
Incidence of deep venous thrombosis (DVT) and bleeding eventshard clinical

Perioperative pharmacological thromboprophylaxis in cancer patients reduces DVT risk but significantly increases bleeding, suggesting extended preoperative LMWH may be the most effective strategy if used.

Cite This Study

Guo et al. (2016) studied this question.

synapsesocial.com/papers/6a82563594037d46bac6ab44https://doi.org/10.1097/sla.0000000000002074

Topics

Pulmonary embolismAnticoagulation in AF
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Also Consider

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  4. 4Effect of low molecular weight heparin (Certoparin) versus unfractionated heparin on cancer survival following breast and pelvic cancer surgery: A prospective randomized double-blind trial.2000 · 121 citations
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