Why the study?
Do matrix metalloproteinases destabilize vulnerable atherosclerotic plaques?
Do matrix metalloproteinases destabilize vulnerable atherosclerotic plaques?
Matrix metalloproteinases play a complex, dual role in atherosclerotic plaque stability, making dysregulated MMP activity in end-stage coronary artery disease a potential therapeutic target.
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Dual MMP roles warrant caution with nonselective inhibitors in CAD; leaves open selective MMP-9/12 modulation as research priority.
Andrew C. Newby (2006) studied this question.
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