Population
Rat phaeochromocytoma cells
Design
Preclinical
Authors
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No immediate clinical implications; extends biophysical models of L-type Ca2+ channel block for further mechanistic studies.
External and internal Mg2+ block L-type Ca2+ channels at the same high-affinity Ca2+ binding sites in the pore, with differing exit rates indicating asymmetric energy barriers.
Kuo et al. (1993) studied this question.
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