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May 18, 2004Hypertension

Activating Mutation of the Renal Epithelial Chloride Channel ClC-Kb Predisposing to Hypertension

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Why the study?

Does the ClC-Kb(T481S) polymorphism increase blood pressure and predispose to hypertension?

Population

Xenopus oocytes and human cohorts including an African population from Ghana and a white population

Comparison

ClC-Kb(T481S) polymorphism vs Wild-type ClC-Kb / non-carriers

Design

Cross-sectional

Authors

NJNikola JeckGoethe University FrankfurtSWSiegfried WaldeggerInnsbruck Medical UniversityALAngelika LampertUniversitätsklinikum Aachen

Discussion

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Member takes

Overview

Supports ClC-Kb(T481S) as a hypertension risk variant in cross-sectional data; leaves open causality and clinical utility pending prospective validation.

Structured PICO

Does the ClC-Kb(T481S) polymorphism increase blood pressure and predispose to hypertension?

P
Population
Xenopus oocytes (in vitro) and human cohorts including an African population from Ghana and a white population (in vivo)
I
Intervention
ClC-Kb(T481S) polymorphism
C
Comparator
Wild-type ClC-Kb / non-carriers
O
Outcome
Chloride channel current (in vitro) and blood pressure levels/hypertension prevalence (in vivo)surrogate

The ClC-Kb(T481S) polymorphism strongly activates the chloride channel in vitro and is associated with significantly higher blood pressure and hypertension prevalence in vivo.

Cite This Study

Jeck et al. (2004) studied this question.

synapsesocial.com/papers/6a82704df2e4e6540e2a599ahttps://doi.org/10.1161/01.hyp.0000129824.12959.f0
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bartter syndrome2003 · 253 citations
  2. 2Molecular Genetics of Human Blood Pressure Variation1996 · 636 citations
  3. 3Salt Wasting and Deafness Resulting from Mutations in Two Chloride Channels2004 · 286 citations
  4. 4Roles of Na-K-2Cl and Na-Cl cotransporters and ROMK potassium channels in urinary concentrating mechanism1998 · 62 citations