Specific amino acids and metal ions can either protect or inactivate the infectivity of poliovirus RNA.
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No immediate clinical implications from this animal study; leaves open further research on amino acid and metal effects on viral RNA.
Most amino acids, except cysteine, protected the infectivity of phenol‐extracted poliovirus ribonucleic acid against inactivation during incubation at 37 C. Of these amino acids, histidine was most effective, whereas cysteine enhanced inactivation. Besides cysteine, three sulfhydryl compounds were also examined. Thioglycolic acid exhibited a similar effect as cysteine, but glutathione and mercaptoethanol were protective or enhancing in the inactivation of poliovirus RNA depending on the concentration of the drug. The effect of metal ions was diverse. Cu ++ and Hg ++ reduced the infectivity extensively, whereas Fe 3+ and Al 3+ were protective. Some of other metal ions were more or less inactivating, while the other metal ions examined were not. A protector and an inactivator of infectious RNA antagonized each other.
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Totsuka et al. (1974) studied this question.
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