Key result
Environmental factors such as salt and sucrose concentration, cell age, nutrition, and temperature alter host cell susceptibility and influence the infectivity of poliovirus RNA.
The physiological state of mammalian host cells significantly influences their susceptibility to poliovirus RNA infectivity.
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Cell culture conditions require standardization in viral assays; leaves open translation to human poliovirus infection.
Evidence presented shows that the influence of salt concentration of the environment on RNA infectivity for mammalian cells is due at least in part to alteration of the state of susceptibility of the host cell. The 3 different cell lines tested simultaneously responded differently when exposed to the same RNA preparation diluted in varying salt concentrations. Other factors which alter host cell susceptibility, sucrose concentration, age of host cell, nutritional environment of host cell and temperature during the adsorption interval, emphasize the importance of the physiological state of the cell at time of exposure to RNA to the degree of infectivity expressed.
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Sprunt et al. (1961) studied Poliovirus RNA infectivity. Varying environmental factors (salt concentration, sucrose, temperature, cell age, nutrition) was evaluated on RNA infectivity for mammalian cells. Environmental factors such as salt and sucrose concentration, cell age, nutrition, and temperature alter host cell susceptibility and influence the infectivity of poliovirus RNA.
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