Validation of lower body negative pressure as an experimental model of hemorrhage

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Population

Sedated baboons

Comparison

Lower body negative pressure at four levels vs Actual hemorrhage at 6.25%, 12.5%, 18.75%, and…

Design

Preclinical

Follow-up

4 weeks between interventions

Authors

Discussion

Supports LBNP as a hypovolemia model in animals; leaves open translation to human research.

Population

Sedated baboons

Intervention

Lower body negative pressure (LBNP) at four levels (-22 ± 6, -41 ± 7, -54 ± 10, and -71 ± 7 mmHg)

Comparator

Actual hemorrhage (Hem) at 6.25%, 12.5%, 18.75%, and 25% of total estimated blood volume

Outcome

Hemodynamic responses (arterial pressure, pulse pressure, central venous pressure, heart rate, stroke volume, and +dP/dt)surrogate

LBNP effectively mimics the integrative cardiovascular response to hemorrhage, validating its use as an experimental model for central hypovolemia.

Hinojosa‐Laborde et al. (2013) studied this question.

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