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December 28, 2025The American Journal of CardiologyOpen Access

Dynamic Changes in Right Ventricular-Pulmonary Arterial Coupling During Acute Heart Failure Hospitalization: Prognostic Implications

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Why the study?

RV-PA uncoupling predicts heart failure outcomes, but dynamic changes during acute HF hospitalization and their prognostic significance remain unclear.

Does persistent RV-PA uncoupling at discharge predict all-cause mortality and HF rehospitalization in hospitalized acute HF patients?

Population

490 consecutive hospitalized acute HF patients

Comparison

Persistent RV-PA uncoupling vs normalized RV-PA uncoupling vs sustained RV-PA coupling

Design

Prospective cohort study

Follow-up

Mean 12.0 ± 2.6 months

Authors

VAVasileios AnastasiouESEvdoxia StavropoulouEPEmmanouela Peteinidou

Discussion

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Member takes

Overview

Serial RV-PA uncoupling assessment during acute HF hospitalization refines prognosis; leaves open whether it guides therapy or improves outcomes in prospective studies.

Structured PICO

Does persistent RV-PA uncoupling at discharge predict all-cause mortality and HF rehospitalization in hospitalized acute HF patients?

P
Population
490 consecutive hospitalized acute heart failure (HF) patients, mean age 73.4 ± 11.9 years.
I
Intervention
Persistent right ventricular-pulmonary arterial (RV-PA) uncoupling (TAPSE/PASP <0.36 mm/mmHg on admission and at discharge)
C
Comparator
RV-PA coupling on admission and discharge, or normalized RV-PA uncoupling (uncoupling on admission that normalized to coupling at discharge)
O
Outcome
Composite of all-cause mortality and HF rehospitalizationcomposite

In hospitalized acute HF patients, persistent RV-PA uncoupling at discharge is a strong independent predictor of 1-year mortality and HF rehospitalization.

Cite This Study

Anastasiou et al. (2025) studied this question.

synapsesocial.com/papers/6a828f9bf5f149803a21dd04https://doi.org/10.1016/j.amjcard.2025.12.010
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