December 1, 2004DiabetesOpen Access

G-Protein Signaling Participates in the Development of Diabetic Cardiomyopathy

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Why the study?

Does modulation of Gq-mediated signaling affect the development of diabetic cardiomyopathy in mouse models?

Structured PICO

Does modulation of Gq-mediated signaling affect the development of diabetic cardiomyopathy in mouse models?

Population

Transgenic mouse models of diabetic cardiomyopathy (PPAR-alpha overexpression mice, RGS4 overexpression mice, mutant Galphaq-G188S mice) and streptozotocin (STZ)-induced diabetic mice

Intervention

Genetic modulation of G-protein signaling (cardiac-specific overexpression of RGS4 or mutant Galphaq-G188S)

Comparator

Control mice without the specific genetic modulation (e.g., PPAR-alpha mice without RGS4 overexpression, or wild-type mice treated with STZ)

Outcome

Development of cardiomyopathic phenotype (cardiac hypertrophy, contractile dysfunction, fetal gene induction, and bradycardia)surrogate

Gq-mediated signaling plays a critical role in the pathogenesis of diabetic cardiomyopathy, highlighting a potential mechanistic pathway for future therapeutic targeting.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May support Gq modulation as a target in diabetic cardiomyopathy; leaves open translation from mouse models to humans.

Cite This Study

Harris et al. (2004) studied this question.

synapsesocial.com/papers/6a8290730f52607ca18ad8f6 https://doi.org/10.2337/diabetes.53.12.3082

Topics

Cardiomyopathy

View Full Paper

Ask AI

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G-Protein Signaling Participates in the Development of Diabetic Cardiomyopathy

Structured PICO

Discussion

Implication

Cite This Study

Topics

G-Protein Signaling Participates in the Development of Diabetic Cardiomyopathy

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider