November 30, 2011CirculationOpen Access

Mice With Cardiac Overexpression of Peroxisome Proliferator–Activated Receptor γ Have Impaired Repolarization and Spontaneous Fatal Ventricular Arrhythmias

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Population

Transgenic mice with cardiac-specific overexpression of peroxisome proliferator-activated receptor γ 1 via…

Comparison

Cardiac-specific overexpression of PPARγ1 and… vs Wild-type mice

Design

Preclinical

Authors

JMJohn MorrowElectrophysiology AKAlexander N. KatchmanColumbia University NSNi-Huiping SonNew York University

Discussion

Member takes

Implication

Raises hypothesis for PPARγ agonist arrhythmogenicity; leaves open whether cardiac PPARγ activation causes human ventricular arrhythmias.

Structured PICO

Population

Transgenic mice with cardiac-specific overexpression of peroxisome proliferator-activated receptor γ 1 (PPARγ1) via the cardiac α-myosin heavy-chain promoter, and wild-type (WT) mice

Intervention

Cardiac-specific overexpression of PPARγ1 and short-term exposure to pioglitazone

Comparator

Wild-type mice

Outcome

Mortality, ECG parameters (QRS and QT intervals), and spontaneous ventricular arrhythmias

Cardiac PPARγ activation and subsequent lipid accumulation cause ion channel remodeling and fatal ventricular arrhythmias in a mouse model.

Cite This Study

Morrow et al. (2011) studied this question.

synapsesocial.com/papers/6a7e1bd941b6b106c97f58ff https://doi.org/10.1161/circulationaha.111.056309

Topics

Ventricular arrhythmias

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Implication

Raises hypothesis for PPARγ agonist arrhythmogenicity; leaves open whether cardiac PPARγ activation causes human ventricular arrhythmias.

Mice With Cardiac Overexpression of Peroxisome Proliferator–Activated Receptor γ Have Impaired Repolarization and Spontaneous Fatal Ventricular Arrhythmias

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Mice With Cardiac Overexpression of Peroxisome Proliferator–Activated Receptor γ Have Impaired Repolarization and Spontaneous Fatal Ventricular Arrhythmias

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

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