Why the study?
Carbon dioxide digital-subtraction angiography is increasingly used in EVAR and F/B-EVAR to reduce iodinated contrast medium and prevent postoperative renal function worsening, prompting a review of literature results and wider aortic applications.
Does carbon dioxide digital-subtraction angiography reduce postoperative renal function worsening compared to iodinated contrast medium in patients undergoing endovascular aortic repair?
Does carbon dioxide digital-subtraction angiography reduce postoperative renal function worsening compared to iodinated contrast medium in patients undergoing endovascular aortic repair?
CO2-DSA is an effective technique for reducing postoperative renal function worsening during EVAR while maintaining acceptable intraoperative arterial visualization.
CO2-DSA may reduce renal worsening in EVAR; leaves open confirmation by prospective randomized trials.
Background/Objectives: Carbon dioxide digital-subtraction angiography (CO2-DSA) is an increasingly adopted technique in endovascular aortic repair (EVAR) and fenestrated/branched EVAR (F/B-EVAR); it is used to reduce the amount of iodinate contrast medium (ICM) and prevent postoperative renal function worsening (PO-RFW). Our aim is to report results from the literature on EVAR and F/B-EVAR procedures using CO2-DSA, together with wider applications in aortic endovascular treatment. Methods: We performed a literature review by searching electronic databases for published data on CO2-DSA during EVAR and F/B-EVAR procedures. The endpoints were postoperative renal function worsening (PO-RFW) and efficacy of intraoperative arterial visualization. Further, applications of CO2 for thoracic endovascular aortic repair (TEVAR) were described. Results: Seventeen studies reporting results on CO2-DSA in EVAR (644 patients) were retrieved. Overall, 372 (58%) procedures were performed with CO2 alone, and 272 (42%) were performed with CO2+ICM. Eight studies analyzed the effect of CO2-DSA angiography on PO-RFW; four studies showed a significantly lower rate of PO-RFW compared to ICM. Five studies (153 patients) analyzed intraoperative arterial visualization with CO2-DSA; renal and hypogastric arteries were effectively visualized in 69% and 99% of cases, respectively. The use of CO2-DSA in F/B-EVAR has not been widely investigated. The largest series reported that PO-RFW was lower in the CO2 vs. ICM group. Conclusions: Carbon dioxide is widely applied in modern aortic endovascular treatment. CO2-DSA for EVAR and F/B-EVAR is an efficient technique for reducing PO-RFW while allowing acceptable arterial intraoperative visualization.
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Spath et al. (2024) studied this question.
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