November 1, 1998Journal of VirologyOpen Access

Vaccinia Virus Protein Synthesis Has a Low Requirement for the Intact Translation Initiation Factor eIF4F, the Cap-Binding Complex, within Infected Cells

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Population

Vaccinia virus-infected cells transfected with plasmid DNAs expressing dicistronic mRNAs

Design

Preclinical

Authors

JMJohn E. MulderThe Pirbright Institute MRM. E. RobertsonUniversity of London RSRachael SeamonsNovartis (Switzerland)

Discussion

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Implication

Hypothesis-generating for poxvirus translation; leaves open eIF4F-targeted antivirals pending mammalian validation.

Structured PICO

Population

Vaccinia virus-infected cells transfected with plasmid DNAs expressing dicistronic mRNAs

Intervention

Coexpression of poliovirus 2A or foot-and-mouth disease virus Lb proteases to cleave translation initiation factor eIF4G

Outcome

Vaccinia virus protein synthesis and cap-dependent protein synthesissurrogate

Late vaccinia virus protein synthesis has a low requirement for the intact cap-binding complex eIF4F, likely due to short unstructured 5' noncoding regions.

Cite This Study

Mulder et al. (1998) studied this question.

synapsesocial.com/papers/6a8293bb576c5bd0156d011b https://doi.org/10.1128/jvi.72.11.8813-8819.1998

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Vaccinia Virus Protein Synthesis Has a Low Requirement for the Intact Translation Initiation Factor eIF4F, the Cap-Binding Complex, within Infected Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Vaccinia Virus Protein Synthesis Has a Low Requirement for the Intact Translation Initiation Factor eIF4F, the Cap-Binding Complex, within Infected Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider