Why the study?
Does intraplaque hemorrhage correlate with the timing of symptoms or severity of stenosis in patients undergoing carotid endarterectomy?
Does intraplaque hemorrhage correlate with the timing of symptoms or severity of stenosis in patients undergoing carotid endarterectomy?
Hemorrhage into carotid plaques serves as an index of stenosis severity and plaque instability rather than playing a direct role in the pathogenesis of transient ischemic attacks or stroke.
Intraplaque hemorrhage was associated with stenosis severity but not symptom timing; leaves open its causal role in carotid events.
We correlated the clinical and pathologic findings in 77 consecutive carotid plaques removed at endarterectomy to determine the clinical role of intraplaque hemorrhage. Intraplaque hemorrhages of various severity were seen in 86% of plaques. They were, for the most part, deeply located (63%) and infrequently connected with the lumen. They related closely to the severity of carotid stenosis, but bore no relationship to the timing of symptoms. Luminal thrombus was infrequently seen, and was always microscopic. Hemorrhage into carotid plaque appears to represent an index of the severity of the stenosis and plaque instability rather than to play a direct role in the pathogenesis of transient ischemic attacks or stroke.
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Bornstein et al. (1990) studied this question.
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