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January 23, 2002JAMA

Chelation Therapy for Ischemic Heart Disease

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Why the study?

Does EDTA chelation therapy improve time to ischemia and quality of life in patients with stable ischemic heart disease?

Population

n=84 adults with stable ischemic heart disease and stable angina while receiving optimal medical therapy…

Comparison

Weight-adjusted EDTA chelation therapy infusion… vs Placebo infusion for 3 hours per treatment…

Design

RCT, Randomly assigned, Double-blind, placebo-controlled

Follow-up

27 weeks

Authors

MKMerril L. Knudtson

Discussion

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Overview

EDTA chelation shows no benefit in stable ischemic heart disease; confirms lack of efficacy and advises against clinical use.

Structured PICO

Does EDTA chelation therapy improve time to ischemia and quality of life in patients with stable ischemic heart disease?

P
Population
n=84 adults (age ≥21 years) with stable ischemic heart disease (coronary artery disease proven by angiography or documented myocardial infarction) and stable angina while receiving optimal medical therapy, demonstrating at least 1-mm ST depression on a qualifying treadmill test. Recruited in Calgary, Alberta.
I
Intervention
Weight-adjusted (40 mg/kg) EDTA chelation therapy infusion for 3 hours per treatment, twice weekly for 15 weeks and once per month for an additional 3 months, plus oral multivitamin therapy.
C
Comparator
Placebo infusion for 3 hours per treatment, twice weekly for 15 weeks and once per month for an additional 3 months, plus oral multivitamin therapy.
O
Outcome
Change from baseline to 27-week follow-up in time to ischemia (1-mm ST depression on treadmill test).surrogate

EDTA chelation therapy does not improve exercise time to ischemia, exercise capacity, or quality of life in patients with stable ischemic heart disease compared to placebo.

Cite This Study

Merril L. Knudtson (2002) studied this question.

synapsesocial.com/papers/6a829d2425bcba1e23d4a4cahttps://doi.org/10.1001/jama.287.4.481
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1So Much Writing, So Little Science: A Review of 37 Years of Literature on Edetate Sodium Chelation Therapy1993 · 42 citations