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December 1, 1993Annals of Pharmacotherapy

So Much Writing, So Little Science: A Review of 37 Years of Literature on Edetate Sodium Chelation Therapy

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Key result

A review of 16 case reports, 2 longitudinal studies, and 3 clinical trials found that edetate sodium (EDTA) chelation therapy is ineffective for treating atherosclerosis.

Why the study?

Does edetate sodium chelation therapy improve outcomes in patients with atherosclerosis?

Population

Patients with atherosclerosis

Design

Systematic_review

Authors

MGMichael T. GrierDMDavid G. MeyersCreighton University

Discussion

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Implication

EDTA chelation should not be used for atherosclerosis; confirms lack of efficacy across reviewed trials and studies.

Structured PICO

Does edetate sodium chelation therapy improve outcomes in patients with atherosclerosis?

P
Population
Patients with atherosclerosis
I
Intervention
Edetate sodium (ethylenediamine tetraacetic acid; EDTA) chelation therapy
O
Outcome
Safety and efficacysafety

EDTA chelation therapy lacks valid scientific evidence for efficacy and should not be used in clinical practice to treat atherosclerosis.

Limitations

  • Little valid scientific evidence is available.

Cite This Study

Grier et al. (1993) conducted a review in atherosclerosis. edetate sodium (EDTA) chelation therapy was evaluated on safety and efficacy. A review of 16 case reports, 2 longitudinal studies, and 3 clinical trials found that edetate sodium (EDTA) chelation therapy is ineffective for treating atherosclerosis.

synapsesocial.com/papers/6a23158a4a04428ad56563f1https://doi.org/10.1177/106002809302701217
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chelation therapy for atherosclerotic cardiovascular disease2002 · 78 citations
  2. 2Apparent Failure of Edetic Acid Chelation Therapy for the Treatment of Coronary Atherosclerosis1990 · 12 citations
  3. 3Effect of Disodium EDTA Chelation Regimen on Cardiovascular Events in Patients With Previous Myocardial Infarction2013 · 272 citations
  4. 4Chelation Therapy of Atherosclerosis1984 · 19 citations
  5. 5LONG TERM RENAL STABILITY WITH DISODIUM EDTA CHELATION IN NON-DIABETIC PATIENT WITH STAGE 3B CKD AND A SOLITARY KIDNEY: A SEVEN YEAR CASE REPORT2025