The downregulation of smooth muscle MyHC B in spontaneously hypertensive rats is likely of genetic origin rather than an adaptive response to hypertension and cardiac hypertrophy.
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Suggests genetic origin for SMB changes in SHR; leaves open relevance to human hypertensive vascular remodeling.
We demonstrated recently a significantly lower fraction of cardiac precapillary arterioles that expressed smooth muscle myosin heavy chain (MyHC) B (SMB) in spontaneously hypertensive rats. To clarify whether this reduction of SMB expression is of genetic origin, we investigated SMB expression in cardiac precapillary arterioles of normotensive and experimentally hypertensive rats (one clip, one kidney or ANG II minipump). We observed similar SMB expression patterns in precapillary arterioles of experimentally hypertensive rats compared with normotensive controls. These observations suggest that the downregulation of SMB in spontaneously hypertensive rats is of genetic origin rather than an adaptive response to chronically enhanced blood pressure and cardiac hypertrophy.
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Wetzel et al. (2003) studied this question.
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