Stem Cell Transplant in Immune-deficiency–associated Vaccine-derived Poliovirus

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  Figure 1.. Neighbor-Joining tree illustrating the accumulation of poliovirus mutations in the patient over time. The evolutionary history was inferred using the Neighbor-Joining method [4] with the tree rooted to Sabin 3. The percentage of replicate trees in which the associated taxa clustered together in the bootstrap test (1000 replicates) are shown next to the branches [5]. The tree is drawn to scale, with branch lengths in the same units as those of the evolutionary distances used to infer the phylogenetic tree. The evolutionary distances were computed using the maximum composite likelihood method [6] and are in the units of the number of base substitutions per site. This analysis involved 9 nucleotide sequences. Codon positions included were 1st+2nd+3rd+ noncoding. All ambiguous positions were removed for each sequence pair (pairwise deletion option). There was a total of 900 positions in the final dataset. Evolutionary analyses were conducted in MEGA11.