Population
Healthy volunteers and simulated data generated with the integral pulse frequency model (IPFM)
Design
Other
Authors
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Standard RR interval analysis may bias autonomic activity estimates; leaves open validation of heart rate-independent alternatives.
Commonly used electrocardiographic RR interval representation of heart-rate variation may yield biased results regarding autonomic activity, suggesting a need for alternative measurement approaches.
Niklasson et al. (1993) studied this question.
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